Search for dissertations about: "TrpF"

Found 4 swedish dissertations containing the word TrpF.

  2. 1. Life will find a way : Structural and evolutionary insights into FusB and HisA

    Author : Xiaohu Guo; Maria Selmer; Joel L. Sussman; Uppsala universitet; []
    Keywords : HisA; TrpF; protein evolution; bi-functional enzyme; fusidic acid; antibiotic resistance; protein synthesis; FusB;

    Abstract : How do microbes adapt to challenges from the environment? In this thesis, two distinct cases were examined through structural and biochemical methods. In the first, we followed a real-time protein evolution of HisA to a novel function. The second case was fusidic acid (FA) resistance mediated by the protein FusB in Staphylococcus aureus. READ MORE

  4. 2. Deciphering molecular mechanisms in the evolution of new functions

    Author : Hind Abdalaal; Joakim Näsvall; Paul Rainey; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolvability; functional trade-offs; collateral toxicity; duplication and amplification; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. READ MORE

  5. 3. Evolution of New Genes and Functions

    Author : Erik Lundin; Dan I Andersson; Joakim Näsvall; Diarmaid Hughes; Arjan de Visser; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : To answer major evolutionary questions, we need a better understanding of the effects of mutations on specific functions and organism fitness. The aim of this thesis was to elucidate how new functions evolve and potential trade-offs with the original function. READ MORE

  6. 4. The Importance of Being Promiscuous : Understanding enzyme function, specificity, and evolution through structure

    Author : Annika Söderholm; Maria Selmer; Birte Höcker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Enzyme evolution; enzyme promiscuity; X-ray crystallography.;

    Abstract : Enzymes are known to be amazingly specific and efficient catalysts. However, many enzymes also have so-called promiscuous functions, i.e., they are able to catalyze other reactions than their main one. READ MORE