Search for dissertations about: "Tumor"

Showing result 16 - 20 of 2208 swedish dissertations containing the word Tumor.

2. 16. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis

   Author : Julia Femel; Anna-Karin Olsson; Grietje (Ingrid) Molema; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor; therapeutic; cancer vaccine; angiogenesis; vasculature; fibronectin; galectin-1; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Science; Medicinsk vetenskap;

   Abstract : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. READ MORE

4. 17. NO, Immunosuppression and Tumor Immmunotherapy

   Author : Pontus Hegardt; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

   Abstract : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. READ MORE

5. 18. Tumor instructed normal tissue : studies of potential extratumoral biomarkers and therapeutic targets in prostate cancer

   Author : Maria Nilsson; Sofia Halin Bergström; Anders Bergh; Kristian Pietras; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; biomarkers; tumor-instructed normal tissue; extra cellular matrix; macrophages; LOX; HO-1; MSMB; Pathology; patologi;

   Abstract : Prostate cancer is the most common cancer in men in Sweden and but luckily the majority of the patients will carry on their life without any consequences from the disease. Unfortunately, some will develop aggressive tumors and eventually die. READ MORE

6. 19. Transforming Growth Factor-b, Regulatory functions on normal lymphocytes and tumor outgrowth Regulatory functions on normal lymphocytes and tumor outgrowth

   Author : Åsa Schiött; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-b; monocyte; rat; costimulation; Th2; ERK; tumor; TIL; Immunology; serology; Immunologi; transplantation; T-lymphocyte; serologi;

   Abstract : Transforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. READ MORE

7. 20. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Author : Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Abstract : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. READ MORE