Search for dissertations about: "UCP-2"

Found 5 swedish dissertations containing the word UCP-2.

  2. 1. Glucocorticoid administration : studies on weight regulation and metabolic implications

    Author : Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

    Abstract : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. READ MORE

  4. 2. Experimental Traumatic Brain Injury and Cell Death - in vivo and in vitro aspects

    Author : Gustav Mattiasson; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsychology; Neurology; uncoupling protein; mitochondrial permeability transition; cerebral blood flow; functional outcome; cell death; mitochondria; hippocampus; preconditioning; trauma; Brain; ischemia; neuropsykologi; Neurologi; neurophysiology;

    Abstract : Traumatic and ischemic brain damage are major causes of disability and death. While much effort has been spent on developing pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. READ MORE

  5. 3. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    Author : Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

  6. 4. Aspects on the modulation of potassium channels in insulin-producing beta-cells

    Author : Zuheng Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : islets of Langerhans; over-stimulation; diazoxide; exocytosis; proteasome; microarray; Kv1.1.;

    Abstract : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. READ MORE

  7. 5. Insulin resistance in pancreatic cancer

    Author : Bengt Isaksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pancreatic cancer; glucose transport; glucose metabolism; insulin signaling; insulin resistance; uncoupling proteins; obstructive jaundice; IAPP; risk factors.;

    Abstract : The dismal prognosis of pancreatic cancer (PC) is related to metabolic complications of the tumor. Impaired glucose tolerance or diabetes due to insulin resistance, and cachexia are observed early and frequently in these patients. The basic mechanisms of PC-associated insulin resistance and weight loss are not fully understood. READ MORE