Search for dissertations about: "UGTs"

Found 5 swedish dissertations containing the word UGTs.

  2. 1. Expression of Genes Encoding for Drug Metabolism in the Small Intestine

    Author : Monica Lindell; Hans Lennernäs; Matti Lang; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; CYPs; UGTs; interindividual variation; small intestine; human; rat; artemisinin; CAR-receptor regulation; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : This investigation focused on the mRNA expression of drug metabolising Cytochromes P-450 (CYP) and UDP-glucuronosyltransferases (UGT) and the transport protein P-glycoprotein (Pgp) in the small intestine of humans and rats.The mRNA expression of the investigated genes in the human small intestine (duodenum) varies between individuals giving each one of us personal profile. READ MORE

  4. 2. Controlling Fusarium Head Blight in oat

    Author : Alfia Khairullina; Tillämpad biokemi; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; FHB; oat; UDP-glucosyltransferase; deoxynivalenol; mycotoxins; biocontrol; Clonostachys rosea; Fusarium head blight; Fusarium graminearum; endophytes;

    Abstract : Oats (Avena sativa) is a versatile crop grown worldwide for animal feed and human consumption. Humanoat consumption has recently risen due to its various health benefits. However, oats are susceptible toFusarium head blight (FHB) caused by various Fusarium fungi. FHB reduces yield and leads to mycotoxinaccumulation. READ MORE

  5. 3. Sex steroid metabolism and body composition

    Author : Charlotte Swanson; Göteborgs universitet; []
    Keywords : UDP glucuronosyltranferases; polymorphisms; androgens; glucuronidated androgen metabolites; fat mass; bone; metabolic risk factors; population study;

    Abstract : Background: The bioactive androgens testosterone (T) and dihydrotestosterone (DHT) regulate bone and fat mass in men. The effects of androgens are largely determined by the rate of their synthesis and inactivation. READ MORE

  6. 4. The role of the prostate in androgen metabolism

    Author : Mats Olsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The androgenic steroid hormones are essential for the physiological development of the prostate gland and are also implicated in pathological processes such as benign prostatic hyperplasia and prostate cancer. The systemic effect of endocrine activity in the prostate gland has so far been considered of minor importance. READ MORE

  7. 5. Charcterization of biotransformation systems in human cells

    Author : Therese Söderdahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Understanding mechanisms of toxicity is an important part of improving safety assessment, but for this, simplified methods and models to screen for mechanisms associated with toxicity are required. READ MORE