Search for dissertations about: "VEGF-A165"

Found 4 swedish dissertations containing the word VEGF-A165.

  2. 1. Myocardial angiogenesis induced by plasmid VEGF-A165 gene transfer : experimental and clinical studies

    Author : Nondita Sarkar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Coronary artery disease; vascular endothelial growth factor; therapeutic angiogenesis; gene transfer; plasmid DNA; gene expression;

    Abstract : New therapeutic options have emerged for patients with medically intractable angina who are not candidates for conventional revascularisation techniques, from increasing understanding of the biology of vessel formation and how different angiogenic growth factors participate in the process. Administration of vascular endothelial growth factor-A165 (VEGF-A165), a key regulator of vessel growth, has been shown to augment myocardial collateral growth. READ MORE

  4. 2. Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods

    Author : Xiaojin Hao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; arteriogenesis; apoptosis; myocardial infarction; VEGF-A165; bFGF; PDGF-BB; adenovirus; plasmid; alginate;

    Abstract : Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the optimal application of growth factors and delivery method requires further exploration. READ MORE

  5. 3. Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation

    Author : Agneta Månsson Broberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myocardial infarction; ischemia; angiogenesis; VEGF- A165; gene therapy; adenovirus; plasmid; ephrinB2; darbepoietin-alpha; apoptosis; estrogen receptors;

    Abstract : Background: Therapeutic angiogenesis using i.e. VEGF and FGF have shown beneficial effects, however, delivery routes and other modulating agents have not been thoroughly investigated. In this study the efficacy of adenovirus gene transfer was compared to plasmid gene transfer. READ MORE

  6. 4. Exercise and angiogenic growth factors in human skeletal muscle

    Author : Thomas Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adapatation; angiogenesis; angiogenic growth factors; blood flow; gene expression; gene regulation; human; ischaemia; skeletal muscle; training;

    Abstract : Long-term electrical stimulation and endurance exercise increase the amount of capillaries in skeletal muscle. VEGF-A is a well-characterized stimulatory angiogenic growth factor and has shown to play an important role in angiogenesis in pathological conditions in humans and in physiological conditions in animal models. READ MORE