Search for dissertations about: "VEGF"

Showing result 21 - 25 of 244 swedish dissertations containing the word VEGF.

  2. 21. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer

    Author : Åke Berglund; Ragnar Hultborn; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Colorectal cancer; chemotherapy; 5-fluorouracil; dose-effect relationship; ex vivo assay; thymidylate synthase; p53; CEA; TPS; VEGF; bFGF.; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Abstract : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. READ MORE

  4. 22. VEGFR-2 in Endothelial Differentiation and Vascular Organization

    Author : Dan Edholm; Lena Claesson-Welsh; Xiujuan Li; Victoria Bautch; Uppsala universitet; []
    Keywords : Molecular medicine; Embryonic stem; VEGFR-2; Flk1; KDR; VEGF; vasculogenesis; angiogenesis; embryoid body; Molekylärmedicin;

    Abstract : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. READ MORE

  5. 23. Pharmacometrics to improve clinical benefit assessment in oncology

    Author : Emilie Schindler; Lena E Friberg; Mats O Karlsson; Rik de Greef; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacokinetics; pharmacodynamics; VEGF; SLD; targeted therapies; IRT; FDG-PET; SUVmax; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). READ MORE

  6. 24. Skeletal muscle in Restless legs syndrome (RLS) and Obstructive sleep apnoea syndrome (OSAS)

    Author : Britta Wåhlin Larsson; Karin Piehl-Aulin; Fawzi Kadi; Jan Ulfberg; Carl-Johan Sundberg; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RLS; OSAS; aerobic capacity; skeletal muscle fibers; capillary; VEGF; Physiology; Fysiologi; Idrottsvetenskap; Sports Science;

    Abstract : Restless legs syndrome (RLS) and Obstructive sleep apnoea syndrome (OSAS) are two sleep disorders that affect daily life with symptoms such as sleepiness and fatigue. It was therefore hypothesised that the skeletal muscle could be affected as symptoms from skeletal muscle are common. READ MORE

  7. 25. Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis

    Author : Wei Jiang; Jukka Jolkkonen; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; neurogenesis; angiogenesis; rats; mice; gliosis; BrdU; CBF; protein synthesis; ATP; penumbra; reperfusion; VEGF; 3-D confocal; photothrombosis; MCAO; Medicine; Medicin;

    Abstract : Background: Ischemic stroke ranks as the third major cause of clinical mortality and the leading cause of handicap in adults. Each year, stroke occurs in about 30,000 Swedes. The severity of an acute ischemic stroke depends mainly on the degree and duration of local cerebral blood flow (lCBF) reduction. READ MORE