Search for dissertations about: "Veronica Tamu Dufe"

Found 1 swedish dissertation containing the words Veronica Tamu Dufe.

2. 1. Structural Studies of Polyamine Biosynthesis Enzymes: Potential Targets for Drugs against Tropical Parasites

   Author : Veronica Tamu Dufe; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; inhibitors; protein crystallography; Molecular biophysics; Molekylär biofysik; tropical parasites; polyamine biosynthesis enzymes;

   Abstract : Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. READ MORE