Search for dissertations about: "Vladimir Sharoyko"

Found 1 swedish dissertation containing the words Vladimir Sharoyko.

2. 1. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282

   Author : Vladimir Sharoyko; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Insulin secretion; pancreatic islets; imidazolines; BL11282; arachidonic acid; phospholipase; cytochrome P-450; GLP-1; desensitization; Rhes;

   Abstract : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. READ MORE