Search for dissertations about: "WIG"

Showing result 1 - 5 of 11 swedish dissertations containing the word WIG.

  2. 1. Cloning and characterization of a p-53-inducible gene, WIG-1

    Author : Shohreh Varmeh-Ziaie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance of many tumor types to chemotherapy and radiotherapy. READ MORE

  4. 2. Molecular studies of Wig-1, a p53-induced zinc finger protein

    Author : Cristina Méndez Vidal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The fact that p53 is one of the most commonly mutated gene in human tumors indicates that it has a key role in tumor suppression. p53 accumulates after DNA-damage and other types of cellular stress, leading to the initiation of a p53-dependent biological response, including cell cycle arrest and apoptosis. READ MORE

  5. 3. Identification, cloning and characterization of the p53 induced gene human Wig-1

    Author : Fredrik Hellborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 is a transcription factor that responds to various kinds of cellular stress. In respons to the sensed stress it is able to induces cell cycle arrest and apoptosis. In order to achieve these effects it transactivates target genes. READ MORE

  6. 4. The p53-induced gene wig-1 : regulation of expression and role in embryonic development

    Author : Margareta Wilhelm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. More than 50% of human tumors carry mutations in the p53 gene, most of which reside within the DNAbinding core domain of p53. READ MORE

  7. 5. The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells

    Author : Magdalena Prahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 is a critical regulator of life and death in cells. The p53 protein is present at very low levels in cells under normal conditions but accumulates in response to different stress stimuli, such as DNA damage, hypoxia, and oncogene activation. READ MORE