Search for dissertations about: "Wimal"

Found 2 swedish dissertations containing the word Wimal.

2. 1. Cox-2 inhibitors of natural origin : Dereplication, isolation, and structure elucidation

   Author : Wimal Pathmasiri; Uppsala universitet; []
   Keywords : ;

   Abstract : .... READ MORE

4. 2. Structural and Biophysical Studies of Nucleic Acids

   Author : Wimal Pathmasiri; Adolf Gogoll; Lena Mäler; Uppsala universitet; []
   Keywords : Organic chemistry; nucleic acids; Nuclear Magnetic Resonance; molecular dynamics; sugar modified nucleosides; pKa; Organisk kemi;

   Abstract : This thesis is based on six research publications concerned with (i) study of the molecular structures and dynamics of modified nucleosides; (ii) investigation of the effect of incorporation of modified nucleosides on the structure of DNA; (iii) examination of the effect of the sugar modifications on the pseudo-aromatic properties (pKa) of the nucleobases; (iv) analysis of the effect of the CH-π interactions on the relative stability of the DNA-RNA hybrid duplexes. The structural stability of the nucleic acids as well as their behavior in molecular recognition is dominated by hydrogen bonding and stacking interactions beside other non-covalent interactions. READ MORE