Search for dissertations about: "Xenograft model"

Showing result 1 - 5 of 39 swedish dissertations containing the words Xenograft model.

  1. 1. The involvement of gangliosides in growth and migration of human glioblastoma cells

    Author : Kristina Hedberg; Göteborgs universitet.; University of Gothenburg.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN; MEDICINE; Neurovetenskap; Neuroscience; Gangliosides synthesis; Ganglioside expression; Glioblastoma; Migration; Proliferation; Cell culture systems; Xenograft model;

    Abstract : Human glioblastoma is a primary brain tumour with a bad prognosis. One major contributing factor is that the tumour grows in an infiltrative way. Single tumour cells, undetectable with today's techniques, invade the brain and escape therapy. READ MORE

  2. 2. Restoration of scarred vocal folds with stem cell implantation: analyses in a xenograft model

    University dissertation from Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology

    Author : Bengt Svensson; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Background: Tissue defects in the vocal fold (VF) caused by trauma, surgical procedures, post radiotherapy often heal with scar formation. The scar tissue causes stiffness of the lamina propria rendering disturbed viscoelastic properties to the VF. A scarred VF causes severe voice problems. READ MORE

  3. 3. HAMLET - In vivo effects and mechanisms of tumor-cell death

    University dissertation from Institute of Laboratory Medicine Department of Microbiology, Immunology and Glycobiology Lund University

    Author : Lotta Gustafsson; Lunds universitet.; Lund University.; [2005]
    Keywords : Biomedical sciences; Biomedicinska vetenskaper; proteasome stress; HAMLET; human milk; tumor-cell death; clinical trial; rat xenograft model; skin papilloma; glioblastoma; Biologi; Biology;

    Abstract : HAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. READ MORE

  4. 4. Using a 3-d model system to screen for drugs effective on solid tumors

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Walid Fayad; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors. READ MORE

  5. 5. Adenovirus-mediated Gene Therapy of Prostate Cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Angelika Danielsson; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adenovirus; adenoviral vector; oncolytic virus; gene therapy; prostate cancer; PEGylation; HDAC inhibitor; whole blood model; whole blood neutralization assay; MEDICINE; MEDICIN; Clinical Immunology; Klinisk immunologi; Molecular Genetics; Molekylär genetik;

    Abstract : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. READ MORE