Search for dissertations about: "Xenograft model"

Showing result 1 - 5 of 52 swedish dissertations containing the words Xenograft model.

  1. 1. Xenograft Rejection : A Study of Cytokine mRNA Expression in Experimental Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Henrik Krook; Uppsala universitet.; [2002]
    Keywords : Medical and Health Sciences Clinical Medicine Cancer and Oncology; Medicin och hälsovetenskap Klinisk medicin Cancer och onkologi; Oncology; Type 1 diabetes; Parkinson’s disease; xenotransplantation; islets; neural tissue; heart; mRNA; cytokines; rejection.; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : Acute cellular xenograft rejection of ICCs triggered mRNA expression of proinflammatory cytokines (IL-1b and TNF-a), Th1 associated cytokines (IL-12p40, IL-2 and IFN-g) and Th2 associated cytokines (IL-4 and IL-10). The peak values and the kinetics of the mRNA expression indicated that acute cellular xenograft rejection is enhanced by the proinflammatory response and mediated by the Th1 associated response, whereas the function of the Th2 associated response most likely is to counteract the Th1 associated cytokines and thereby inhibit bystander damage by the delayed type hypersensitivity like rejection process. READ MORE

  2. 2. Experimental studies on xenograft rejection

    University dissertation from Stockholm : Karolinska Institutet, Department of Surgical Science

    Author : Guosheng Wu; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms and give new clues for prevention of xenorejection, thereby hopefully contributing to the development of clinical xenotransplantation. READ MORE

  3. 3. Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment

    University dissertation from Surgery (Lund)

    Author : Daniel Ansari; Lunds universitet.; Lund University.; [2014]
    Keywords : apicidin; artificial neural networks; centralization; early detection; epigenetics; high definition mass spectrometry; MUC4; pancreatic cancer; pancreaticoduodenectomy; prognostic factors; xenograft model; treatment; MEDICIN; MEDICINE;

    Abstract : Background: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. READ MORE

  4. 4. The involvement of gangliosides in growth and migration of human glioblastoma cells

    University dissertation from Surgery (Lund)

    Author : Kristina Hedberg; Göteborgs universitet.; University of Gothenburg.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN; MEDICINE; Neurovetenskap; Neuroscience; Gangliosides synthesis; Ganglioside expression; Glioblastoma; Migration; Proliferation; Cell culture systems; Xenograft model;

    Abstract : Human glioblastoma is a primary brain tumour with a bad prognosis. One major contributing factor is that the tumour grows in an infiltrative way. Single tumour cells, undetectable with today's techniques, invade the brain and escape therapy. READ MORE

  5. 5. Restoration of scarred vocal folds with stem cell implantation: analyses in a xenograft model

    University dissertation from Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology

    Author : Bengt Svensson; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Background: Tissue defects in the vocal fold (VF) caused by trauma, surgical procedures, post radiotherapy often heal with scar formation. The scar tissue causes stiffness of the lamina propria rendering disturbed viscoelastic properties to the VF. A scarred VF causes severe voice problems. READ MORE