Search for dissertations about: "aberrant cyclin E"

Found 5 swedish dissertations containing the words aberrant cyclin E.

2. 1. Cyclin A and cyclin E as prognostic factors in early breast cancer

   Author : Cecilia Ahlin; Marie-Louise Fjällskog; Carl Blomqvist; Göran Landberg; Uppsala universitet; []
   Keywords : Oncology; breast cancer; chemotherapy; cyclin A; cyclin E; aberrant cyclin E; Ki-67; TMA; Onkologi;

   Abstract : Breast cancer is one of the most common malignancies in women. Due to early detection and the use of screening programs approximately 60% of all new cases lack lymph node involvement. Today, a substantial proportion of these women will be offered adjuvant systemic chemotherapy. READ MORE

4. 2. Alterations of cell cycle control genes in human astrocytomas

   Author : Esther E Schmidt; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cytogenetic analyses and molecular genetic studies have revealed a number of chromosomal regions deleted or amplified in astrocytic tumors, presumably harboring tumor suppressor genes and oncogenes involved in astrocytic oncogenesis. Astrocytomas represent the most common subgroup of primary intracranial tumors. READ MORE

5. 3. Cyclin E overexpression and associated events in human breast cancer

   Author : Maria Stighall; Malmö Patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; tumour growth pattern; invasion; proliferation; ID2; cyclin E; pRb; cell cycle; breast cancer;

   Abstract : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. READ MORE

6. 4. Cell Cycle Regulation in Human Renal Cell Carcinoma

   Author : Ylva Hedberg; Göran Landberg; Börje Ljungberg; Göran Roos; Ulf Bergerheim; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Human Renal Cell Carcinoma; Cell Cycle; G1 S; Protein; Cyclin; p27; pRb; Phosphorylation; Tissue Microarray; Clinical Behaviour; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : ABSTRACTCell cycle regulation in human renal cell carcinomaYlva Hedberg, Departments of Medical Biosciences, Pathology, and Surgical andPerioperative Sciences, Urology Andrology, Umeå University, SwedenDeregulated growth control is a hallmark of neoplasia potentially caused by aberrant expression of cell cycle regulatory proteins. The importance of such aberrations in human renal cell carcinoma (RCC) has not been fully clarified. READ MORE

7. 5. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

   Author : Melker Göransson; Göteborgs universitet; []
   Keywords : Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

   Abstract : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. READ MORE