Search for dissertations about: "acetylcholinesterase"
Showing result 1 - 5 of 30 swedish dissertations containing the word acetylcholinesterase.
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1. Mammalian brain acetylcholinesterase : a study of its solubilization, purification, molecular state and interactions with cholinergic ligands including an endogenous modulator
Abstract : Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. READ MORE
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2. Towards Mosquitocides for Prevention of Vector-Borne Infectious Diseases : discovery and Development of Acetylcholinesterase 1 Inhibitors
Abstract : Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. READ MORE
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3. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase
Abstract : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. READ MORE
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4. Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes : design and development of new insecticides for vector control
Abstract : Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for insecticides. READ MORE
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5. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase
Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE