Search for dissertations about: "adenoviral vector"
Showing result 1 - 5 of 15 swedish dissertations containing the words adenoviral vector.
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1. In vitro Studies of β-cell Death and Survival. Modulation by Adenoviral Vectors and Bcl-2 Overexpression
Abstract : Type 1 diabetes is a multifactorial disease resulting from the selective destruction of insulin-producing β-cells within the pancreatic islets of Langerhans. The mechanisms of β-cell death are not fully understood but cytokines are important mediators of this process. READ MORE
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2. Adenovirus-mediated Gene Therapy of Prostate Cancer
Abstract : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. READ MORE
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3. Allogeneic dendritic cells as adjuvants in cancer immunotherapy
Abstract : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. READ MORE
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4. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer
Abstract : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. READ MORE
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5. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer
Abstract : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. READ MORE