Search for dissertations about: "adenylyl cyclase"
Showing result 1 - 5 of 30 swedish dissertations containing the words adenylyl cyclase.
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1. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk
Abstract : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. READ MORE
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2. G-proteins and adenylyl cyclase in Alzheimer's disease postmortem brain
Abstract : Alzheimer's disease (AD) is the most common type of dementia in the elderly. The major pathological changes seen in the disease are the formation of neurofibrillary tangles, of which the main component is the hyperphosphorylated form of tau, and the over accumulation of plaques formed by beta-amyloid. READ MORE
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3. The human undescended testis and the effect of HCG treatment : a study of the morphology, in vitro progesterone metabolism, gonadotrophin receptors and germ cell adenylyl cyclase in testicular biopsies
Abstract : .... READ MORE
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4. Signaling via Orexin Receptors : A Pharmacological Study
Abstract : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. READ MORE
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5. Mechanisms of impaired insulin release in type-2 diabetes : studies in the GK rat model
Abstract : Type-2 diabetes is a complex syndrome with a polygenic and multifactorial aetiology. It is characterised by its relatively late appearance in life and its mild progressive course. Glucose intolerance can generally be ascribed to disturbed pancreatic hormonal secretion and/or insulin resistance in the liver and extrahepatic tissues. READ MORE