Search for dissertations about: "albumin binding domain"
Showing result 11 - 15 of 35 swedish dissertations containing the words albumin binding domain.
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11. Interaction engineered three-helix bundle domains for protein recovery and detection
Abstract : HTML clipboard The great advances in DNA technology, e.g. sequencing and recombinant DNA techniques, have given us the genetic information and the tools needed to effectively produce recombinant proteins. Recombinant proteins are valuable means in biotechnological applications and are also emerging as alternatives in therapeutic applications. READ MORE
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12. Development of ADAPT-based tracers for radionuclide molecular imaging of cancer
Abstract : ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT binders against various therapeutic targets can be selected. READ MORE
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13. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy
Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE
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14. Engineering of small IgG binding domains for antibody labelling and purification
Abstract : In protein engineering, rational design and selection from combinatorial libraries are methods used to develop proteins with new or improved features. A very important protein for the biological sciences is the antibody that is used as a detecting agent in numerous laboratory assays. READ MORE
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15. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications
Abstract : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. READ MORE