Search for dissertations about: "albumin binding domain"
Showing result 6 - 10 of 35 swedish dissertations containing the words albumin binding domain.
-
6. Engineering of staphylococcal surfaces for biotechnological applications
Abstract : The engineering of bacterial surfaces has in recent yearsattracted a lot of attention with applications in manydifferent areas of bioscience. Here we describe the use of twodifferent surface display systems for the gram-positivebacteria Staphylococcus carnosus and Staphylococcus xylosus invarious biotechnological applications. READ MORE
-
7. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications
Abstract : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. READ MORE
-
8. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications
Abstract : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. READ MORE
-
9. Development of molecular recognition by rational and combinatorial engineering
Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE
-
10. Chemical Engineering of Small Affinity Proteins
Abstract : Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. READ MORE