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Showing result 1 - 5 of 45 swedish dissertations matching the above criteria.

  2. 1. Studies on alcoholic liver disease

    Author : Knut Stokkeland; Karolinska Institutet; Karolinska Institutet; []
    Keywords : alcohol cirrhosis; cytochromes; autoantibodies; mortality; morbidity; prognosis; epidemiology; esophageal varices; lifetime drinking; lifetime alcohol intake;

    Abstract : The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of autoantibodies in the pathogenesis of alcohol related liver disease. We found that rats had appearance of IgG against rat CYP3A 1 and CYP2E 1 during chronic ethanol feeding We found that patients had reactivity against CYP3A4 and CYP2E I in about 20 to 30% and 10 to 20% of the alcoholic sera. READ MORE

  4. 2. Non-Alcoholic Fatty Liver Disease : A clinical and histopathological study

    Author : Mattias Ekstedt; Stergios Kechagias; Stefan Lindgren; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterology; Gastroenterologi;

    Abstract : Fatty liver has previously often been associated with excessive alcohol consumption. During the last two decades, the interest in fatty liver occurring in non-drinkers i.e. non-alcoholic fatty liver disease (NAFLD) has increased dramatically. READ MORE

  5. 3. Non-Alcoholic Fatty Liver Disease : Aspects on Diagnosis and Long-term Prognosis

    Author : Patrik Nasr; Stergios Kechagias; Mattias Ekstedt; Peter Lundberg; Einar Stefán Björnsson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease affecting approximately 25% of the global population and is commonly recognized as the hepatic manifestation of the metabolic syndrome. The histological spectrum of NAFLD ranges from isolated steatosis to non-alcoholic steatohepatitis (NASH), with risk of developing fibrosis and subsequent cirrhosis and hepatocellular carcinoma. READ MORE

  6. 4. Non-Alcoholic Fatty Liver Disease : Insights into Alcohol Consumption, Genetics, and Proteomics

    Author : Julia Blomdahl; Stergios Kechagias; Mattias Ekstedt; Maja Thiele; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : NAFLD (Non-Alcoholic Fatty Liver Disease) affects approximately a quarter of the global population and is closely linked to type 2 diabetes mellitus and obesity. The disease spectrum ranges from steatosis and steatohepatitis to fibrosis, cirrhosis, and hepatocellular cancer. READ MORE

  7. 5. Non-alcoholic fatty liver disease : an emerging liver disease

    Author : Cecilia Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of the study was to evaluate what NAFLD is from a molecular perspective, what influences the disease progression and what the prognosis of the disease is. Fatty liver has earlier often been associated with excessive alcohol intake and only in the last two decades has it been viewed as a condition in non- drinkers i.e. READ MORE