Search for dissertations about: "amino acid residue"

Showing result 1 - 5 of 69 swedish dissertations containing the words amino acid residue.

  1. 1. Exploring amino-acid radicals and quinone redox chemistry in model proteins

    University dissertation from Stockholm : Institutionen för biokemi och biofysik

    Author : Kristina Westerlund; Stockholms universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amino-acid radicals; quinone redox chemistry; model proteins; protein redesign; electrochemistry; ODONTOLOGY Biochemistry; ODONTOLOGI Biokemi; biokemi; Biochemistry;

    Abstract : Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. READ MORE

  2. 2. Expanding the Amino Acid Alphabet by Design Enhanced and Controlled Catalytic Activity in Folded Polypeptide Catalysts

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : N. Johan V. Lindgren; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry; MEDICIN Kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis addresses structure and reactivity of polypeptide catalysts in reactions that mimic the hydrolysis of RNA and DNA. A designed helix-loop-helix motif was used as a scaffold where the amino acid residues were systematically varied. READ MORE

  3. 3. Expression of Manganese Lipoxygenase and Site-Directed Mutagenesis of Catalytically Important Amino Acids Studies on Fatty Acid Dioxygenases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mirela Cristea; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Dioxygenase; Gaeumannomyces graminis; lipoxygenase; Magnaporthe grisea; oxylipin; Pichia pastoris; hydroperoxide isomerase; polyunsaturated fatty acids; Farmaceutisk farmakologi; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi;

    Abstract : Polyunsaturated fatty acids can be bioactivated by two families of dioxygenases, which either contain non-heme iron (lipoxygenases) or heme (cyclooxygenases, linoleate diol synthases and α-dioxygenases).Lipoxygenases and their products play important roles in the pathophysiology of plants and fungi. READ MORE

  4. 4. Protein Surfaces Probed by Aqueous Two-phase Partitioning

    University dissertation from Department of Biochemistry, Lund University

    Author : Kristina Berggren; Lunds universitet.; Lund University.; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolism; partitioning; Aqueous two-phase systems; protein surface; peptide; Biochemistry; amino acid residue; Biokemi;

    Abstract : This thesis is concerned primarily with peptide and protein partitioning in aqueous two-phase systems and the connection between partitioning behavior and protein structure. The surface properties of a protein is often crucial for recognition and interaction with other molecules. READ MORE

  5. 5. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Usama M. Hegazy; Uppsala universitet.; [2006]
    Keywords : Biochemistry; Glutathione transferase; targeted chemical modification; lock-and-key motif; cooperativity; stucture-function relationship; protein engineering; unnatural amino acid; site-specific mutation; Biokemi;

    Abstract : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. READ MORE