Search for dissertations about: "aneuploid"

Showing result 1 - 5 of 43 swedish dissertations containing the word aneuploid.

  2. 1. The fate of primary aneuploid cells in early embryonic development and stem cells

    Author : Daniel Aaron Lightfoot; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mosaic; aneuploid; embryo; gastrulation; ES cell; SYCP3;

    Abstract : Chromosomal aberrations occurring during gametogenesis and early embryonic development play a significant role in infertility and fetal loss in humans. Germ cells that have an abnormal number of chromosomes (aneuploidy) are generated mainly due to errors during female gamete formation, a phenomenon increasing in occurrence with age. READ MORE

  4. 2. Genome instability, gene expression and prognosis in breast cancer

    Author : Ulrike Kronenwett; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast adenocarcinoma; genomic instability; SSI; centrosomes;

    Abstract : Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid subtype of breast carcinoma that proved to be genomically stable. READ MORE

  5. 3. Identification of protein signatures of genomic stability/instability in epithelial cancers

    Author : Timo Gemoll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aneuploidy is a consistent genetic alteration of the cancer genome. At early steps in the sequence of malignant transformation during human tumorigenesis, chromosomal aneuploidies can be the first detectable genetic aberrations found. READ MORE

  6. 4. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Author : Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Abstract : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. READ MORE

  7. 5. The role of endogenous hypercholecystokininemia and hypergastrinemia in growth and carcinogenesis of the exocrine pancreas

    Author : Ming Chu; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The gut hormones cholecystokinin (CCK) and gastrin are phylogeneticallyand structurally related. Under normal conditions, CCK regulates growth of the exocrine pancreas and gastrin growth of the oxyntic mucosa of the stomach. READ MORE