Search for dissertations about: "angiostatin"

Found 4 swedish dissertations containing the word angiostatin.

  2. 1. Angiostatic mechanisms of endogenous angiogenesis inhibitors

    Author : Niina Veitonmäki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; tumor growth; angiostatin; K 1 - 5; adiponectin; hTERT; p16;

    Abstract : Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor nearly 10 years ago. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. READ MORE

  4. 2. The role of angiomotin in endothelial cell motility and cell-cell junction formation

    Author : Anders Bratt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; cancer; angiostatin; angiomotin; cell motility cell-cell junction; tight junction; adherens junction;

    Abstract : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. READ MORE

  5. 3. The role of angiomotin in angiogenesis

    Author : Tanya Levchenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Angiogenesis plays key roles during embryonic development, female reproduction and wound repair. Angiogenesis, the formation of new blood vessels from of pre-existing capillaries, is a process tightly regulated by a balance between positive and negative regulators. READ MORE

  6. 4. Positive and negative angiogenic factors in patients with malignant disease

    Author : Christina Linder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : angiogenesis; neovascularization; microvessel density; VEGF; bFGF; stromelysin-3;

    Abstract : In this thesis, the levels of positive and negative angiogenic factors were studied in tissue, serum and urine from patients with malignant disease. The angiogenic factors VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) were studied in breast carcinomas. READ MORE