Search for dissertations about: "anti- CD40L"

Showing result 1 - 5 of 17 swedish dissertations containing the words anti- CD40L.

2. 1. CD40L Gene Therapy for Solid Tumors

   Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

   Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE

4. 2. Induction of operational tolerance to allografts and xenografts

   Author : Matthias Corbascio; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; allograft; xenograft; heart transplantation; tolerance; anti-LFA-1; CTLA4Ig; anti-CD40L;

   Abstract : Inhibition of the costimulatory molecules B7 and CD40L with CTLA4Ig and anti-CD40L administered only during the first week after transplantation induces indefinite survival of allo- and xenogeneic heart transplants and significantly prolongs skin grafts in C3H mice. However, this treatment protocol is not as effective in C57BL/6 mice which reject skin transplants with nearly the same median survival time as untreated controls. READ MORE

5. 3. Costimulation Blockade in Experimental Transplantation

   Author : Helene Malm; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; serologi; Immunologi; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; graft survival; anti-CD40L; CTLA4Ig; anti-LFA-1; costimulation blockade;

   Abstract : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. READ MORE

6. 4. Intratumoral CD40 stimulating therapy in patients with advanced cancer

   Author : Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Abstract : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. READ MORE

7. 5. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

   Author : Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

   Abstract : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. READ MORE