Search for dissertations about: "anti-epileptic drugs"

Showing result 1 - 5 of 10 swedish dissertations containing the words anti-epileptic drugs.

2. 1. Anti-epileptic and neuroprotective mechanisms by Topiramate and Levetiracetam evaluated in primary cultures

   Author : Mikael Ängehagen; Göteborgs universitet; []
   Keywords : calcium imaging; phosphorylation; kainate; glutamate; caffeine; cerebral cortex; hippocampus; field potentials; neurons; astrocytes;

   Abstract : The aim of this thesis was to evaluate plausible intracellular mechanisms of action for antiepileptic drugs, Topiramate (TPM) and Levetiracetam (LEV), and to investigate if TPM possesses neuroprotective properties. The thesis is based on results from calcium imaging, immunohistochemical stainings, viability tests, and Western blot using primary cortical or hippocampal cultures, or hippocampal brain slices. READ MORE

4. 2. Epilepsy in young adulthood : medical, psychosocial and functional aspects

   Author : Helena Gauffin; Anne-Marie Landtblom; Birgitta Söderfeldt; Maria Engström; Thomas Karlsson; Lena Räty; Elinor Ben-Menachem; Linköpings universitet; []
   Keywords : Epilepsy; young adult; Quality of Life; self-esteem; daily life; antiepileptic drugs; cognition; language; fMRI; Sence of Coherence;

   Abstract : The aim of this thesis was to describe the medical, cognitive and psychosocial consequences of epilepsy in young adulthood. Four studies were carried out with this patient group. READ MORE

5. 3. Posterior ocular malformations in children : teratological aspects

   Author : Kristina Teär Fahnehjelm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Teratology; ocular malformations; visual impairment; anti-epileptic drugs; congenital infection; optic nerve hypoplasia; coloboma; magnetic resonance imaging; neonatal cholestasis; dried blood spots;

   Abstract : Posterior ocular malformations are common causes of visual impairment in Swedish children. The most frequent diagnoses within this group are optic nerve hypoplasia and optic nerve/chorioretinal coloboma. Genetic factors, teratogens like medical/addictive drugs or congenital infections and unknown factors may cause these malformations. READ MORE

6. 4. The Burden of Epilepsy : using population-based data to define the burden and model a cost-effective intervention for the treatment of epilepsy in rural South Africa

   Author : Ryan G Wagner; Lars Lindholm; Lars Forsgren; Charles Newton; Andrea Winkler; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Africa; epilepsy; incidence; mortality; cause of death; disability-adjusted life years; out-of-pocket; costs; health care utilization; treatment cascade; adherence; intervention; economic evaluation; community health worker;

   Abstract : Rationale Epilepsy is a common, chronic, neurological condition that disproportionately affects individuals living in low- and middle- income countries, including much of sub-Saharan Africa. Epilepsy is treatable, with the majority of individuals who take anti-epileptic drugs experiencing a reduction, or elimination, of seizures. READ MORE

7. 5. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Author : Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Abstract : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. READ MORE