Search for dissertations about: "antibiotic resistance"

Showing result 11 - 15 of 352 swedish dissertations containing the words antibiotic resistance.

2. 11. Mechanisms of Antibiotic Resistance Evolution

   Author : Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

   Abstract : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. READ MORE

4. 12. Selection of Resistance at very low Antibiotic Concentrations

   Author : Erik Gullberg; Dan I Andersson; Diarmaid Hughes; Linus Sandegren; Laura Piddock; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Selection; Antibiotic resistant bacteria; Minimal inhibitory concentration; Heavy metals; Conjugative plasmid; ESBL; Mikrobiologi; Microbiology; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Abstract : The extensive medical and agricultural use and misuse of antibiotics during the last 70 years has caused an enrichment of resistant pathogenic bacteria that now severely threatens our capacity to efficiently treat bacterial infections. While is has been known for a long time that high concentrations of antibiotics can select for resistant mutants, less is known about the lower limit at which antibiotics can be selective and enrich for resistant bacteria. READ MORE

5. 13. Antibiotic resistance in the environment: a contribution from metagenomic studies

   Author : Johan Bengtsson-Palme; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; metagenomics; bioinformatics; next generation sequencing; resistance selection;

   Abstract : Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting that the environment plays an important role in the progression of resistance. READ MORE

6. 14. Evolution of Antibiotic Resistance

   Author : Franziska Pietsch; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
   Keywords : ciprofloxacin; rifampicin; bacterial fitness; compensation; mutation rate; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE

7. 15. Antimicrobials in sewage treatment plants : occurrence, fate and resistance

   Author : Marcus Östman; Mats Tysklind; Jerker Fick; Erik Björn; Klaus Kümmerer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biocides; antibiotics; sewage treatment plants; wastewater; sludge; ozonation; activated carbon; antibiotic resistance; antimicrobials; mass flows; LC-MS MS; environment; advanced water treatment;

   Abstract : The World Health Organization (WHO) has identified antibiotic resistance as a major threat to human health. The environment has been suggested to play an important role in the emergence of antibiotic resistant bacteria. The external environment can act as a source of resistance genes that could potentially be transferred into human pathogens. READ MORE