Search for dissertations about: "antibiotic resistance"

Showing result 16 - 20 of 352 swedish dissertations containing the words antibiotic resistance.

  2. 16. From Penicillin Binding Proteins to Community Interventions : Mathematical and Statistical Models Related to Antibiotic Resistance

    Author : Patricia Geli Rolfhamre; Åke Svensson; Mikael Andersson; Dan I. Andersson; Karl Ekdahl; Bruce R. Levin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; mathematical modeling; pharmacokinetics; pharmacodynamics; penicillin binding protein; postantibiotic effect; reversibility; selection; community intervention; Mathematical statistics; Matematisk statistik; matematisk statistik; Mathematical Statistics;

    Abstract : Antibiotic resistance has become a major public health concern and mathematical models are important analytical tools for the understanding, evaluation and prediction of the resistance problem and related control strategies.The risk of emerging antibiotic resistance and selection has rarely been a concern in the design of antibiotic drug dosing regimens. READ MORE

  4. 17. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Author : Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Abstract : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. READ MORE

  5. 18. Antibiotic resistance in the pan-genome of E. coli

    Author : Jennifer Jagdmann; Hervé Nicoloff; Dan I. Andersson; Alex O´Neill; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; pan-genome; genetic diversity; plasmids; Mikrobiologi; Microbiology;

    Abstract : The pan-genome of a species is made up of all gene families that can be included in any individual isolate of the species. Escherichia coli (E. coli) has an open pan-genome including at least 128000 gene families, while only about half of the genes found in each individual isolate are common to all isolates. READ MORE

  6. 19. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids

    Author : Sandesh Kanchugal P; Maria Selmer; Ditlev Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; streptomycin; spectinomycin; X-ray crystallography; methyltransferase; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE

  7. 20. Antibiotic Resistance: A Multimethod Investigation of Individual Responsibility and Behaviour

    Author : Mirko Ancillotti; Stefan Eriksson; Jessica Nihlén Fahlquist; Dan I. Andersson; Alberto Giubilini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Behavior; Health Behavior; Health Belief Model; Discrete Choice Experiment; Preferences; Bioethics; Empirical bioethics; Moral responsibility; Justice; Policy demandingness; Virtue ethics; Bioetik; Bioethics;

    Abstract : The rapid development of antibiotic resistance is directly related to how antibiotics are used in society. The international effort to decrease and optimise the use of antibiotics should be sustained by the development of policies that are sensitive to social and cultural contexts. READ MORE