Search for dissertations about: "antibody therapeutics"
Showing result 1 - 5 of 33 swedish dissertations containing the words antibody therapeutics.
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1. Selection and design in antibody phage display
Abstract : The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. READ MORE
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2. Design, expression, and analysis of antibody-based blood-brain barrier shuttles
Abstract : Antibody therapeutics, with their strong and highly selective target binding, are now used to treat various diseases. However, to enable their use to treat brain disorders, they must be delivered across the blood-brain barrier (BBB), as without active transport, only around 0.01% of intravenously injected doses reach the brain. READ MORE
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3. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations
Abstract : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. READ MORE
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4. Utilizing Solid Phase Cloning, Surface Display And Epitope Information for Antibody Generation and Characterization
Abstract : Antibodies have become indispensable tools in diagnostics, research and as therapeutics. There are several strategies to generate monoclonal antibodies (mAbs) in order to avoid the drawbacks of polyclonal antibodies (pAbs) for therapeutic use. READ MORE
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5. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments
Abstract : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. READ MORE