Search for dissertations about: "anticancer study"

Showing result 6 - 10 of 64 swedish dissertations containing the words anticancer study.

  2. 6. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

    Author : Elin Jonsson; Uppsala universitet; []
    Keywords : Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE

  4. 7. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

    Author : Christopher Polonyi; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

    Abstract : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. READ MORE

  5. 8. Pharmacometrics to improve evaluation and individualization of anticancer drug treatment

    Author : Sreenath Madathil Krishnan; Lena Friberg; Mats Karlsson; Zinnia Parra Gillén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacodynamics; survival modeling;

    Abstract : The success rate in clinical development of newer anti-cancer molecules is the lowest compared to other major diseases. Improving the success rate and better early evaluation of efficacy of anti-cancer drugs remain challenging obstacles. READ MORE

  6. 9. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae

    Author : Mattias Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. READ MORE

  7. 10. Mathematical model development to investigate the pharmacokinetic variability of two anticancer drugs

    Author : Martin Fransson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pharmacokinetic variability in a population is the variability in plasma drug concentrations among individuals. It may, for instance, be caused by differences in genes coding for drug-transport proteins and metabolizing enzymes, amount of body fat, age, sex, patient compliance, diet or disease progression. READ MORE