Search for dissertations about: "anticoagulants in vitro efficacy"
Found 3 swedish dissertations containing the words anticoagulants in vitro efficacy.
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1. How to reduce the exposure to anticoagulants when performing haemodialysis in patients with a bleeding risk : a study of methods used in clinical practise
Abstract : When a patient suffers from kidney failure and also has an enhanced risk of bleeding, the standard haemodialysis (HD) treatment becomes a problem. When human blood comes in contact with artificial material, as in the tubing system and in the dialyser (the extra corporeal circuit, ECC), the coagulation system is activated. READ MORE
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2. Early assessment of efficacy and safety of novel anticoagulants as exemplified by direct thrombin inhibitors. Non-clinical pharmacodynamic studies in vitro and in vivo
Abstract : The drawbacks of today's anticoagulants are parenteral use (heparins), a narrow interval between efficacy and bleeding, and the high variability of effect with a consequent need for frequent monitoring (coumarins). The aim of the current studies was to evaluate properties important for efficacy and safety of novel anticoagulants, as exemplified by direct thrombin inhibitors, with non-clinical methods. READ MORE
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3. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation
Abstract : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. READ MORE