Search for dissertations about: "antiepileptic activity"

Showing result 1 - 5 of 18 swedish dissertations containing the words antiepileptic activity.

  2. 1. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

    Author : Faranak Azarbayjani; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. READ MORE

  4. 2. Living with epilepsy : young people with uncomplicated epilepsy and adults with newly debuted epilepsy

    Author : Lena Räty; Matti Sillanpää; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; antiepileptic drug; attitude; epilepsy; health; self-concept; self-esteem; seizure type; seizure control; sense of coherence; quality of life; MEDICINE; MEDICIN; Nursing Science;

    Abstract : The aim of this thesis was to illuminate experiences of living with uncomplicated epilepsy, i.e. epilepsy without any associated neurological impainnents. The focus was on young people, aged 13- 22 (II, III, IV), and adults, aged 18-65 (I), with newly debuted epilepsy, i. READ MORE

  5. 3. Epilepsy in young adulthood : medical, psychosocial and functional aspects

    Author : Helena Gauffin; Anne-Marie Landtblom; Birgitta Söderfeldt; Maria Engström; Thomas Karlsson; Lena Räty; Elinor Ben-Menachem; Linköpings universitet; []
    Keywords : Epilepsy; young adult; Quality of Life; self-esteem; daily life; antiepileptic drugs; cognition; language; fMRI; Sence of Coherence;

    Abstract : The aim of this thesis was to describe the medical, cognitive and psychosocial consequences of epilepsy in young adulthood. Four studies were carried out with this patient group. READ MORE

  6. 4. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Author : Andreas Toft Sörensen; Experimentell Epilepsi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Abstract : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. READ MORE

  7. 5. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy

    Author : Ann-Sofie Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : High-performance liquid chromatography; Antiepileptic drugs; Therapeutic drug monitoring; Lamotrigine; Carbamazepine; Epilepsy; Children; Lennox-Gastaut; Efficacy; CSF; [gamma]aminobuturic acid; Glutamate; Aspartate; Glycine; EEG;

    Abstract : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. READ MORE