Search for dissertations about: "antigen receptor signaling"

Showing result 1 - 5 of 69 swedish dissertations containing the words antigen receptor signaling.

  2. 1. Regulation of B cell development by antigen receptors

    Author : Jannek Hauser; Thomas Grundström; Yuan Zhuang; Umeå universitet; []
    Keywords : calcium; calmodulin; e-proteins; E2A; B cell development; antigen receptor signaling; surrogate light chains; RAG; allelic exclusion; V D J recombination; AID; negative feedback regulation; plasma cell differentiation;

    Abstract : The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. READ MORE

  4. 2. TRAPC : a novel triggering receptor expressed on antigen presenting cells

    Author : Rutger van der Holst; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TREM; DAP12; Receptors; Signaling; Antigen presenting cells;

    Abstract : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. READ MORE

  5. 3. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

    Author : Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

    Abstract : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. READ MORE

  6. 4. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Author : Karin Rödström; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Abstract : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. READ MORE

  7. 5. CAR T cells for Immunotherapy of Cancer

    Author : Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

    Abstract : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. READ MORE