Search for dissertations about: "antigen-presenting cells"

Showing result 1 - 5 of 169 swedish dissertations containing the words antigen-presenting cells.

2. 1. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

   Author : Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

   Abstract : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. READ MORE

4. 2. TRAPC : a novel triggering receptor expressed on antigen presenting cells

   Author : Rutger van der Holst; Karolinska Institutet; Karolinska Institutet; []
   Keywords : TREM; DAP12; Receptors; Signaling; Antigen presenting cells;

   Abstract : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. READ MORE

5. 3. Specific targeting of antigen-presenting cells for immunotherapy

   Author : Sissela Broos; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. READ MORE

6. 4. Peripheral immunity in patients with autoimmune endocrine diseases and the influence of physiological adaptions during pregnancy

   Author : Louise Magnusson; Per-Ola Carlsson; Rosaura Casas; Ola Winqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Hashimoto´s thyroiditis; Graves´ disease; autoimmune Addison´s disease; antigen-presenting cells; B cells; non-classical monocytes; NK cells; memory CD8 T cells; CDCP1; SLAMF1; inflammation; lymphocyte activation; pregnancy; β-cell function; C-peptide; plasma proteome; prolactin; prokineticin-1; glucagon; oral glucose tolerance test; mass cytometry; proximity extension assay; Medicinsk vetenskap; Medical Science; Klinisk immunologi; Clinical Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Abstract : Type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), Graves’ disease (GD), and autoimmune Addison’s disease (AD) appear to share immunogenetic mechanisms. This idea is not novel, as “autoimmune tautology” is an established concept. READ MORE

7. 5. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide

   Author : Eva Dahlén; Lunds universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; Linomide; costimulation; TNF-a; dendritic cells; Diabetes; macrophages; diabetology; Endokrinologi; sekretion; diabetologi; Immunology; serology; transplantation; Immunologi; serologi;

   Abstract : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. READ MORE