Search for dissertations about: "antitumour"

Showing result 1 - 5 of 16 swedish dissertations containing the word antitumour.

  2. 1. Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity

    Author : Petra Lindholm; Anders Backlund; Lars Bohlin; Kristín Ingólfsdóttir; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; pharmacognosy; cytotoxicity; antitumour; Nuphar alkaloid; cyclotide; thionin; cardiac glycoside; Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : The development of resistance by tumour cells to chemotherapeutic agents is a major problem in cancer treatments. One way to counter this is to find compounds with cytotoxic mechanisms other than those of drugs in clinical use today. READ MORE

  4. 2. Tumour models in vitro : on the use of multicellular spheroids in studies of antitumour drugs

    Author : Thore Nederman; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  5. 3. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

    Author : Elin Jonsson; Uppsala universitet; []
    Keywords : Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE

  6. 4. Pharmacological Studies of CHS 828 and Etoposide Induced Tumour Cell Death

    Author : Petra Martinsson; Stig Linder; Uppsala universitet; []
    Keywords : Medical sciences; Cancer chemotherapy; cell death; caspase; etoposide; CHS 828; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : Antitumour properties of the cyanoguanidine CHS 828 and analogues were discovered in 1997. CHS 828 is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. READ MORE

  7. 5. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention

    Author : Andreas Ekborn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cisplatin; ototoxicity; pharmacokinetics; monohydrated complex of cisplatin; protection;

    Abstract : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. READ MORE