Search for dissertations about: "apoptosis pathway in leukemia"

Showing result 1 - 5 of 19 swedish dissertations containing the words apoptosis pathway in leukemia.

  2. 1. Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia

    Author : Anna Olsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B-CLL; apoptosis; TRAIL; FLIP; Bmf; Bfl-1;

    Abstract : B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, disease progression and resistance to therapy in BCLL. READ MORE

  4. 2. The FLT3 Tyrosine Kinase in Leukemia : Deciphering the Downstream Signaling Events and Drug-Escape Mechanisms

    Author : Amanda Nordigården; Jan-Ingvar Jönsson; Mickael Sigvardsson; Alexander Vener; Bengt Hallberg; Linköpings universitet; []
    Keywords : ;

    Abstract : Acute myeloid leukemia (AML) is a severe disease, which originates in blood-forming cells. Although major advances in understanding the biology of AML, the majority of patients eventually succumb to the disease. READ MORE

  5. 3. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

    Author : Karina Vidovic; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1 delZ ; leukemia; BCR ABL1; hematopoiesis; NDRG2; IRF8; WT1;

    Abstract : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. READ MORE

  6. 4. Mechanistic studies of APR-246 in leukemia

    Author : Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. READ MORE

  7. 5. Roles of Myc and Mad in cell cycle and apoptosis

    Author : Ami Albihn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myc; Mad; cell cycle; apoptosis; differentiation; tumorigenesis; chemotherapy;

    Abstract : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. READ MORE