Search for dissertations about: "apoptotic signaling"

Showing result 1 - 5 of 122 swedish dissertations containing the words apoptotic signaling.

2. 1. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

   Author : Stefan Broselid; Drug Target Discovery; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AKAP5; AKAP; MAGUK; cAMP signaling; constitutive signaling; signalosome; GPER; GPR30; GPCR; cytokeratin; RAMP3; apoptotic signaling; breast cancer; PDZ; PDZ-ligand;

   Abstract : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. READ MORE

4. 2. Elucidation of pro-apoptotic signaling induced by cisplatin

   Author : Aleksandra Mandic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Keywords: Cisplatin; apoptosis; signal transduction; Bak; calpain; endoplasmic reticulum;

   Abstract : A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. READ MORE

5. 3. On the pro-apoptotic signaling induced by interferon-alpha

   Author : Linn Hjortsberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used as an active drug in the treatment of malignant diseases for almost five decades. It has shown beneficial results in several hematological malignancies, as well as solid tumors, including hairy cell leukemia, multiple myeloma, chronic myeloid leukemia, renal carcinoma and malignant melanoma. READ MORE

6. 4. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

   Author : Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

   Abstract : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. READ MORE

7. 5. Tissue Factor regulation, signaling and functions beyond coagulation with a focus on diabetes

   Author : Desireé Edén; Agneta Siegbahn; Sofia Ramström; Uppsala universitet; []
   Keywords : Tissue factor; diabetes; cell signaling; coagulation; beta cells; adipocytes; apoptosis; lipolysis; micro RNA; Medicinsk vetenskap; Medical Science;

   Abstract : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein best known for initiating the coagulation cascade upon binding of its ligand FVIIa. Apart from its physiological role in coagulation, TF and TF/FVIIa signaling has proved to be involved in diseases such as diabetes, cancer and cardiovascular diseases. READ MORE