Search for dissertations about: "at2 receptor"

Showing result 1 - 5 of 17 swedish dissertations containing the words at2 receptor.

  2. 1. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

    Author : Christian Sköld; Anders Karlén; Anders Hallberg; Torbjörn Lundstedt; Tommy Liljefors; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; Angiotensin II; AT1; AT2; SAR; bioactive conformation; turn mimetic; peptidomimetic; DISCO; homology model; 3D-QSAR; CoMFA; Farmaceutisk kemi;

    Abstract : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). READ MORE

  4. 2. Design and Synthesis of Novel AT2 Receptor Ligands : From Peptides to Drug-Like Molecules

    Author : Jennie Georgsson; Anders Hallberg; Kevin Burgess; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; angiotensin II; AT1; AT2; AT2 receptor agonist; peptidomimetics; γ-turn mimetics; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : Many peptide receptors are of pharmaceutical interest and there is thus a need for new ligands for such receptors. Unfortunately, peptides are not suitable as orally administrated drugs since they are associated with poor absorption, rapid metabolism and low sub-receptor selectivity. READ MORE

  5. 3. Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders

    Author : Ivan Dimitrijevic; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ischemic heart disease; resistance artery; giant cell arteritis; temporal artery; immunohistochemistry; AT2 receptor; AT1 receptor; Endothelin-1; ETA receptor; ETB receptor;

    Abstract : The present thesis is aimed to examine the hypothesis that the degree of vascular inflammation correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). READ MORE

  6. 4. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Author : Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Keywords : AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Abstract : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. READ MORE

  7. 5. On angiotensin II receptor type 2 receptors in the small intestine

    Author : Sara Ewert; Göteborgs universitet; []
    Keywords : renin-angiotensin; angiotensin; small intestine; mucosa; epithelium; AT1; AT2; bradykinin; BK2 receptor; nitric oxide; iNOS; smooth muscle; contractility;

    Abstract : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. READ MORE