Search for dissertations about: "autocrine loop"

Showing result 1 - 5 of 20 swedish dissertations containing the words autocrine loop.

2. 1. Molecular studies of genetic changes in myxoid and round cell liposarcoma

   Author : Sofia Järnum; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

   Abstract : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. READ MORE

4. 2. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

   Author : Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
   Keywords : Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

   Abstract : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. READ MORE

5. 3. Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas

   Author : Over Cabrera; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets in patients who suffer from the long term side effects of diabetes and insulin therapy. READ MORE

6. 4. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis

   Author : Eugenia Colón; Karolinska Institutet; Karolinska Institutet; []
   Keywords : IGFs; steroidogenesis; Leydig cells; steroidogenic acute regulatory protein StAR ; insulin; IGFBP-3; IGFBP-2 and steroidogenic enzymes;

   Abstract : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. READ MORE

7. 5. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo

   Author : Xiao-Qun Zhang; Hubert Schorle; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Autorcrine PDGF; promoter; PDGFRA; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. READ MORE