Search for dissertations about: "azide"

Showing result 1 - 5 of 42 swedish dissertations containing the word azide.

2. 1. Synthesis of Nitrogen Heterocycles via 1,3-Dipolar Cycloadditions - Method Development and Applications

   Author : Johan Johansson; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2D NOESY; alkyne; 3-dipolar cycloaddition; azomethine ylide; 1; CNTs; azide; sequential one-pot; SEM EDS; microwave heating; RuAAC; CuAAC;

   Abstract : Because of the diverse properties displayed by nitrogen heterocycles, they are one of the most commonly used structural elements in drug discovery. Due to this variation in properties, however, the chemistry and synthetic pathway to each heterocycle is unique. READ MORE

4. 2. Perfluroaryl azides : Reactivities, Unique Reactions and their Applications in the Synthesis of Theranostic Agents

   Author : Sheng Xie; Mingdi Yan; Olof Ramström; Stefan Bräse; KTH; []
   Keywords : Click Chemistry; Dipolar Cycloaddition; Enamine; Triazoline; Amidine; Aggregation-induced emission; pure nanodrugs; aryl amide; thioacid azide reaction; nucleophilic aromatic substitution; azide-masked fluorophore; nitrene insertion; Kemi; Chemistry;

   Abstract : The work centersaround perfluoroaryl azides (PFAAs), and theirability to undergo certain fast and robusttransformations. The chemistry was furtherappliedfor biomedical applications.The first section focuses on the azide-aldehyde-amine cycloaddition using PFAAs. READ MORE

5. 3. Aromatic Allylation via Diazotization; Application in synthesis of heterocyclic compounds

   Author : Fredrik Ek; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bengamide analogue.; parallel synthesis; trimethylsilyl azide; cycloaddition; imidazole; fused tetrazole derivatives; iodocyclization; benzazepine; tert-butyl nitrite; allylic bromide; aromatic allylation; diazotization; Organic chemistry; Organisk kemi;

   Abstract : A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. READ MORE

6. 4. Lewis acid Mediated Aza-Diels-Alder Reactions and Asymmetric Alkylations of 2H-azirines

   Author : Erik Risberg; KTH; []
   Keywords : Enantioselective; diastereoselective; vinyl azide; 2H-azirines; aziridines; Lewis acid; chiral ligand; chiral auxiliary organolithiums Diels-Alder reaction alkyl radicals triethylborane.;

   Abstract : This thesis describes the use of 2H-azirines, three-membered unsaturatednitrogen-containing heterocycles, as reactive intermediates ina number of Lewis acid promoted alkylations and Diels-Alderreactions providing synthetically useful aziridines. In order to carry out this investigation a new generalprocedure for the ring closure of vinyl azides, forming theresultant 3-substituted-2H-azirines, was developed applying low boiling solventsin closed reaction vessels at elevated temperatures. READ MORE

7. 5. Carbohydrate-Functionalized Nanomaterials : Synthesis, Characterization and Biorecognition Studies

   Author : Na Kong; Mingdi Yan; Joseph J. Barchi Jr; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbohydrate; glyconanomaterials; perfluorophenyl azide PFPA ; CuAAC; AAAC; coupling chemistry; 19 F q NMR; lectin; carbon nanomaterials; microwave irradiation; Kemi; Chemistry; Bioteknologi; Biotechnology;

   Abstract : This thesis focuses on the development of carbohydrate coupling chemistry on nanomaterials and their biological activity studies. It is divided into two parts:In part one, two carbohydrate immobilization approaches, based on perfluorophenyl azide (PFPA)-functionalized silica nanoparticles (SNPs), are presented, where the binding affinity of the glyconanoparticles was evaluated through carbohydrate-lectin interaction. READ MORE