Search for dissertations about: "bacteriophage"

Showing result 1 - 5 of 78 swedish dissertations containing the word bacteriophage.

2. 1. Structural Studies of Bacteriophage PRR1 and HIV-1 protease

   Author : Magnus Persson; Lars Liljas; Kaspars Tars; Félix Rey; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRR1; HIV; Structural Biology; X-ray crystallography; PRR1; HIV-1 protease; NCS; crystallography; inhibitor; virus; bacteriophage; X-ray crystallography; Virology; Virologi; Molecular biology; Molekylärbiologi;

   Abstract : Viruses are a diverse genera of organisms adapted to thrive in many different hosts from prokaryotic to eukaryotic.We present here the structure of bacteriophage PRR1 virus-like particle (VLP), belonging to Leviviridae family. Our structure reveals calcium ions in the VLP. READ MORE

4. 2. Control of Quasi-Equivalence in Virus Capsids

   Author : Charlotte Helgstrand; B. V. Venkataram Prasad; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; crystallography; bacteriophage; virus; RNA; capsid; quasi-equivalence; assembly; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Abstract : Many T=3 plant and insect viruses use a molecular switch in form of order/disorder of a segment of the polypeptide chain to regulate the quasi-equivalent contacts. The structure of a mutant of the T=3 capsid of bacteriophage fr confirms that this virus and other members of the Leviviridae family lack a switch mechanism. READ MORE

5. 3. Engineering of Antibacterial Phage-Derived Proteins

   Author : Fredrik Seijsing; Anders Nilsson; Yves Briers; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; endolysin; IgG; linker protein; chimeric protein; artificial opsonin; spider silk; antibacterial surface; bacteriophage; structure prediction; molekylär biovetenskap; Molecular Bioscience;

   Abstract : The increasing threat of antibiotic resistance calls for the development of new treatment methods. Bacteriophages are interesting candidates since they can lyse bacteria with great efficiency. Bacteriophages produce enzymes called endolysins which break down the peptidoglycan in the cell wall at the end of the infection cycle. READ MORE

6. 4. Structure-Function Studies of Bacteriophage P2 Integrase and Cox protein

   Author : Jesper Eriksson; Elisabeth Haggård; Karin Hammer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bacteriophage P2; site-specific recombination; integrase; transcriptional switch; Genetics; Genetik;

   Abstract : Probably no group of organisms has been as important as bacteriophages when it comes to the understanding of fundamental biological processes like transcriptional control, DNA replication, site-specific recombination, e.t.c.The work presented in this thesis is a contribution towards the complete understanding of these organisms. READ MORE

7. 5. Structural Studies of Large dsDNA Viruses using Single Particle Methods

   Author : Hemanth Kumar Narayana Reddy; Martin Svenda; Sarah Butcher; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PR772; phage; PRD1; Bacteriophage; coliphage; Melbournevirus; Cedratvirus; lurbo; Pithovirus; CryoEM; Single particle imaging; Coherent; Diffractive; Imaging; Soft X-ray; Microscopy; Microscope; GDVN; High resolution; XFEL; aerosol; Injection; electrospray; gas dynamic virtual nozzle; CDI; CXI; FEL; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

   Abstract : Structural studies of large biological assemblies pose a unique problem due to their size, complexity and heterogeneity. Conventional methods like x-ray crystallography, NMR, etc. are limited in their ability to address these issues. To overcome some of these limitations, single particle methods were used. READ MORE