Search for dissertations about: "basal cell"
Showing result 1 - 5 of 400 swedish dissertations containing the words basal cell.
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1. Consequences of Shb Deficiency on Hematopoietic Cell Function
Abstract : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. READ MORE
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2. Molecular Analysis of Normal Human Skin and Basal Cell Carcinoma Using Microdissection Based Methods
Abstract : The aim of this thesis was to gain further insight into the biology of normal human skin and basal cell carcinoma (BCC). Morphology in combination with microdissection was used as primary tool for sampling. READ MORE
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3. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes
Abstract : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. READ MORE
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4. ATP Dynamics in Pancreatic α- and β-cells
Abstract : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. READ MORE
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5. Frk/Shb Signalling in Pancreatic Beta-cells : Roles in Islet Function, Beta-cell Development and Survival as Implicated in Mouse Knockout Models
Abstract : The adaptor protein Shb and the non-receptor tyrosine kinase Frk have been implicated in intracellular signalling in insulin-producing beta cells. In this thesis, knockout mice are used to further elucidate the role of Shb and Frk for beta cell number, cytokine-induced cell death, and glucose homeostasis. READ MORE