Search for dissertations about: "beta-2-microglobulin"

Showing result 1 - 5 of 10 swedish dissertations containing the word beta-2-microglobulin.

  2. 1. PLASMA PROTEINS IN NORMAL AND PREECLAMPTIC PREGNANCY

    Author : Karl Kristensen; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; andrology; reproduction; sexuality; Obstetrik; Obstetrics; pregnancy; renal function; serum amyloid A protein; Clinical chemistry; Klinisk kemi; preeclampsia; beta-2 microglobulin; C-reactive protein; cystatin C; inflammation; placenta; beta trace protein; gynekologi; andrologi; reproduktion; sexualitet;

    Abstract : The aim of the research presented in this thesis was to provide extended background knowledge concerning several biochemical markers, used for the medical evaluation of pregnant women with suspected or confirmed preeclampsia, in order to improve the reliability of monitoring. Plasma levels of beta-2 microglobulin, cystatin C and beta trace protein are known to reflect renal filtration in non-pregnant settings, and the plasma proteins, C-reactive protein and serum amyloid A protein, are known to be sensitive markers of inflammation. READ MORE

  4. 2. Neurochemical and neuroendocrine reactions during non-neurological surgery

    Author : Rolf Anckarsäter; Göteborgs universitet; []
    Keywords : albumin; beta-2-microglobulin; blood brain barrier; cerebrospinal fluid; infammation; spinal anesthesia; stress;

    Abstract : Abstract Objective: To study changes in serum and cerebrospinal fluid (CSF) proteins, monoamine metabolites and hormones during non-neurological surgery. Subjects and methods: Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, three hours after and on the morning after surgery. READ MORE

  5. 3. Antiretroviral treatment of HIV-1 in the central nervous system

    Author : Aylin Yilmaz; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Abstract : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. READ MORE

  6. 4. Uveal melanoma : cytogenetics, molecular biology and tumor immunology

    Author : Charlotta All-Ericsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Uveal melanoma; prognostic markers; treatment; CGH; chromosomal aberrations; HLA; IHC; Western blotting; IGF-1R; c-kit; STT571;

    Abstract : Uveal melanoma is the most common primary intraocular malignancy. The metastatic spread is hematogenous and exclusively to the liver. Although eye-sparing treatments are used more frequently the tumor-related mortality in uveal melanoma is still 30-50%. Only 2% of the patients have detectable metastases at the time of diagnosis. READ MORE

  7. 5. Expression and function of ribozymes in transgenic mice

    Author : Michael Andäng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hammerhead ribozyme; hairpin ribozyme; transgenic mice; HIV-1; pseudotype virus; cleavage products; cis-cleavage;

    Abstract : Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by cleaving a target RNA after hybridization to complementary sequences. By changing the specific target hybridization sequence of the ribozyme, virtually any RNA can be targeted, making ribozymes a versatile tool for gene down-regulation (knockdown). READ MORE