Search for dissertations about: "biokemi"

Showing result 1 - 5 of 1493 swedish dissertations containing the word biokemi.

  1. 1. Interpreting a Giant Studies of Structure and Function of Tripeptidyl-peptidase II

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sandra Eklund; Uppsala universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tripeptidyl-peptidas II; molecular ruler; sequence signatures; pH-dependence; endopeptidase; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; Biokemi; Biochemistry;

    Abstract : Tripeptidyl-peptidase II (TPP II) is a subtilisin-like serine peptidase that forms a gigantic homooligomeric complex, and is involved in the degradation of peptides in the cytosol. In addition, TPP II has been implicated in specific cellular processes, such as apoptosis control and adipogenesis, but if this is dependent on its endo- or exopeptidase activity remains to be determined. READ MORE

  2. 2. Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Wei Zhang; Uppsala universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; azathioprine; directed evolution; semi-rational design; catalytic mechanism; saturation mutagenesis; reduced amino acid alphabets; molecular docking; protein evolution; multivariate data analysis; epistasis; fitness landscape; evolutionary trajectories; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; Biokemi; Biochemistry;

    Abstract : Directed evolution is generally regarded as a useful approach in protein engineering. By subjecting members of a mutant library to the power of Darwinian evolution, desired protein properties are obtained. Numerous reports have appeared in the literature showing the success of tailoring proteins for various applications by this method. READ MORE

  3. 3. Structural studies on the integral membrane protein, ubiquinol oxidase from Escherichia coli

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jeff Abramson; Uppsala universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; crystal structure; ubiquinol oxidase; membrane protein; oxidases; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Heme-copper oxidases are redox-driven proton pumps that couple the reduction of molecular oxygen to water with the vectorial translocation of protons across the membrane. The proton gradient generated by heme-copper oxidases and the other members of the aerobic respiratory chain is ultimately used to drive the synthesis of ATP. READ MORE

  4. 4. Partition chromatography of drugs on immobilized liposomes and biomembranes : A method applicable to screening in drug design

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Farideh Beigi; Uppsala universitet.; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : One of the main pathways for drug passage into cells is diffusion across the lipid bilayer ofthe cell membrane. A key factor in this process is the drug partitioning into the bilayer, whichcan be translated into a retention in a chromatographic system. READ MORE

  5. 5. Multiple Functions of Glutathione Transferases A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maryam Edalat; Uppsala universitet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a proper protection system. Glutathione transferases (GSTs) are important components of the cellular defense against oxidative stress. These proteins appear to be suited for different tasks. READ MORE