Search for dissertations about: "biological testing"

Showing result 1 - 5 of 227 swedish dissertations containing the words biological testing.

  2. 1. Mine the Gaps : Evolution of Eukaryotic Protein Indels and their Application for Testing Deep Phylogeny

    Author : Pravech Ajawatanawong; Sandra Baldauf; James McInerney; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; indel; insertion deletion; protein evolution; bioinformatics; non-bilateria; eukaryotes; phylogeny; Biology with specialization in Systematics; Biologi med inriktning mot systematik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : Insertions/deletions (indels) are potentially powerful evolutionary markers, but little is known about their evolution and few tools exist to effectively study them. To address this, I developed SeqFIRE, a tool for automated identification and extraction of indels from protein multiple sequence alignments. READ MORE

  4. 2. Surviving the ratchet : Modelling deleterious mutations in asexual populations

    Author : Jonas Söderberg; Otto Berg; Laurence Loewe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Theoretical biology; Population genetics; Stochastic modelling; Genome evolution; Muller s Ratchet; Genetics; Genetik; Organism biology; Organismbiologi; Biology; Biologi; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely. READ MORE

  5. 3. Evaluation of Morphed Human Body Models for Diverse Occupant Safety Analysis

    Author : Karl-Johan Larsson; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Diversity; Morphing; Validation; Virtual testing; Safety; Human body model;

    Abstract : Female, obese, and elderly occupants are at increased risk of injury in vehicle accidents. Human Body Models (HBMs) are used to represent the human anatomy and to study injury mechanisms in mathematical crash test simulations. READ MORE

  6. 4. Model-Based Hypothesis Testing in Biomedicine : How Systems Biology Can Drive the Growth of Scientific Knowledge

    Author : Rikard Johansson; Gunnar Cedersund; Tomas Strömberg; Peter Strålfors; Marija Cvijovic; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; systems biology; modeling; ODE; hypothesis testing; falsificationism; insulin signaling; yeast; population heterogeneity; cell-to-cell variation; facilitation; pyramidal; synaptic; bootstrapping; personalized medicine; omics;

    Abstract : The utilization of mathematical tools within biology and medicine has traditionally been less widespread compared to other hard sciences, such as physics and chemistry. However, an increased need for tools such as data processing, bioinformatics, statistics, and mathematical modeling, have emerged due to advancements during the last decades. READ MORE

  7. 5. In vitro toxicity testing using human pluripotent stem cell derivatives

    Author : Gustav Holmgren; Anders Lindahl; Jane Synnergren; Peter Sartipy; Chris Denning; Sahlgrenska Academy at University of Gothenburg; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicity testing; human pluripotent stem cells; cardiomyocytes; hepatocytes; microarray; quantitative proteomics; bioinformatics; transcriptomics; microRNA; Medical sciences; Medicin; Bioinformatik; Bioinformatics;

    Abstract : .... READ MORE