Search for dissertations about: "bone tumours"

Showing result 1 - 5 of 32 swedish dissertations containing the words bone tumours.

2. 1. Biomaterials as carriers for bone active molecules-An approach to create off-the-shelf bone substitutes

   Author : Deepak Raina; Lund Ortopedi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomaterials; Bone tissue engineering; Bone morphogenic protein-2; Zoledronic acid ZA ; calcium sulphate; Hydroxyapatite; Gelatin;

   Abstract : Bone tissue is commonly transplanted during orthopedic surgeries, primarily for the management of bone defects caused by trauma or various orthopedic conditions including, but not limited to, infections and tumours. Bone grafts are a surgeon’s choice, but their associated drawbacks are paving the way for biomaterial based bone graft substitutes. READ MORE

4. 2. Genomic and Transcriptomic Analyses of Osteogenic Tumours of Bone

   Author : Karim Saba; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Primary tumours of bone are heterogenous and infrequent neoplasms. Distinguishing between benign, intermediate and malignant entities can in some instances pose a clinical challenge. For some tumour types, there is still much to be learned about the genetic mechanisms that give rise to and drive these tumours forward. READ MORE

5. 3. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

   Author : David Gisselsson Nord; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

   Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE

6. 4. Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment

   Author : Johanna Svensson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radionuclide therapy; Neuroendocrine tumours; 177Lu-DOTATATE; dosimetry; normal tissue response;

   Abstract : Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable patient benefits and is well tolerated. However, renal and bone marrow toxicity can become dose limiting and persisting. READ MORE

7. 5. Modern Staging in Primary Breast Cancer-aspects of micrometastatic disease in bone marrow and molecular profiles in lymph node metastases

   Author : Anna-Karin Falck; Lund Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; biomarker expression; lymph node metastases; relapse; molecular subtype classification; disseminated tumour cells; bone marrow; prognosis; mode of detection;

   Abstract : Breast cancer is a heterogeneous disease with variations in the biological profile and subsequent clinical prognosis. Molecular mechanisms for tumour progression are currently being explored in scientific settings, suggesting parallel evolution of tumour cells at primary and metastatic locations. READ MORE