Search for dissertations about: "branched DNA"
Showing result 1 - 5 of 9 swedish dissertations containing the words branched DNA.
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1. Porphyrin Anchored DNA: Advances in DNA Nanotechnology
Abstract : DNA nanotechnology has focused on the creation of complex structures using DNA as building blocks. DNA is an attractive construction material at the nano scale due to the self-assembly and specific base-pairing of the DNA bases, allowing the placement of functional groups with sub-nm precision. READ MORE
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2. A study of DNA interactive proteins and their origin from thermophilic Siphoviridae phages
Abstract : This thesis covers the results of studies on the amino acid sequence, three-dimensional structure, and activities of two types of DNA-interactive proteins: Holliday Junction resolving enzyme (represented by Hjc_15-6 isolated from phage Tth15-6) and DNA Polymerase I (represented by PolI_G20c, isolated from phage G20c), including studies on their homologous counterparts. As these proteins originate from two different, but related phages that infect Thermus thermophilus, the studies also include the evolutionary relationship between these and other related phages at genomic level. READ MORE
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3. Padlock Probes and Rolling Circle Amplification : New Possibilities for Sensitive Gene Detection
Abstract : A series of novel methods for detection of known sequence variants in DNA, in particular single nucleotide polymorphism, using padlock probes and rolling circle replication are presented. DNA probes that can be circularized – padlock probes – are ideal for rolling circle replication. READ MORE
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4. Nanostructured surfaces created by the interactions of dendrimers and oppositely charged amphiphiles
Abstract : The research described in this thesis aims to understand the interactions between cationic poly(amidoamine) (PAMAM) dendrimers and small oppositely charged amphiphiles at the solid-liquid and air-liquid interfaces in relation to the bulk solution behavior. There is high interest in PAMAM dendrimers because they are well-defined polymers with a hierarchical architecture which makes them promising materials as nanocapsules and gene vectors. READ MORE
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5. DNA double-strand break repair in ascomycetes
Abstract : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. READ MORE