Search for dissertations about: "c-erbb2"

Found 4 swedish dissertations containing the word c-erbb2.

  2. 1. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

    Author : Shahram Hedjazifar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

    Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

  4. 2. Molecular factors influencing epithelial-mesenchymal transition in breast cancer

    Author : Gisela M A Nilsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; epithelial-mesenchymal transition; c-erbB2; E-cadherin; NFI-C2; FoxF1; LOX;

    Abstract : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. READ MORE

  5. 3. Effects of c-erbB2 signaling on morphogenesis and cell adhesion in mammary epithelial cells

    Author : Lachmi E Jenndahl; Göteborgs universitet; []
    Keywords : e-erbB2; integrin alpha2beta1; integrin regulation; ILK; PKB; Rho; epithelial-mesenchymal transition EMT ; E-cadherin; Anchorage independent growth AIG ;

    Abstract : .... READ MORE

  6. 4. Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas

    Author : Anju Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; cervical cancer; oncogene; gene amplification; hTERT;

    Abstract : Characterization of human tumors with associated genetic changes is of importance for better understanding the tumor's basic biological behavior and of great value for clinical management of cancer patients. We therefore investigated oncogene amplifications in human breast and cervical carcinomas using molecular and cytogenetic methods, especially FISH. READ MORE