Search for dissertations about: "calbindin D28k"

Found 5 swedish dissertations containing the words calbindin D28k.

  2. 1. Protein Interactions: Electrostatics and Ligand Binding

    Author : Ingemar André; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; secondary structure formation; protein GB1; pKa values; pH stability; NMR; electrostatic interactions; M proteins; calbindin D9k; calcium binding; cooperativity; calmodulin; calbindin D28k;

    Abstract : This thesis deals with Ca2+ binding to proteins, electrostatic interactions in and between proteins as well as inter- and intramolecular interactions. A computer program was developed to determine Ca2+ binding constants from experimental titration data of proteins. READ MORE

  4. 2. Exploring the interactome of EF-hand proteins

    Author : Mikael Bauer; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; EF-hand; calcium; STIM; stromal interaction molecule; secretagogin; Calmodulin; calbindin D28k; protein-protein interactions; zinc; protein array;

    Abstract : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. READ MORE

  5. 3. Calcium binding protein immunoreactivity in the central auditory system and correlations with the auditory periphery : the effects of noise and aging in mice

    Author : Esma Idrizbegovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Auditory; hearing loss; central auditory system; stereology; plasticity;

    Abstract : This study has examined how calcium binding protein immunoreactivity is modulated in the cochlear nucleus and the inferior colliculus after noise exposure and during aging in mice. The effect of noise exposure on calbindin-D28k (calbindin) and parvalbumin immunoreactivity in the dorsal and posteroventral cochlear nucleus (DCN and PVCN) and inferior colliculus (IC) was studied in CBA/CBA mice by using two-dimensional quantification. READ MORE

  6. 4. Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland

    Author : Arash Hellysaz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome stressors, and generates outputs that affect the autonomic nervous system, the endocrine system and somatomotor behaviors. READ MORE

  7. 5. Calcium-binding proteins as markers and functional determinants of neurons in pain networks

    Author : Mingdong Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord of three species, mouse, rat and human, and their possible roles in pathophysiological pain. In Paper I and Paper IV, we report that the expression of secretagogin is limited to a small subpopulation of peptidergic neurons in mouse and human DRGs expressing calcitonin generelated peptide (CGRP). READ MORE