Search for dissertations about: "calcineurin inhibitors"

Found 3 swedish dissertations containing the words calcineurin inhibitors.

  1. 1. Renal function after transplantation of the liver and intestine

    Author : Gustaf Herlenius; Göteborgs universitet.; Gothenburg University.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adult liver transplantation; pediatric liver transplantation; intestinal transplantation; multivisceral transplantation; immunosuppression; calcineurin inhibitors; glomerular filtration rate; renal function; nephrotoxicity; chronic kidney disease; renal replacement therapy; mortality;

    Abstract : Background: Chronic kidney disease (CKD) after liver (LT) or intestinal (IT) transplantation may decrease patient survival. Calcineurin inhibitors (CNI) play a major role in its development. Aims: Describe long term renal function and risk factors for developing CKD in adults and children after LT and IT. READ MORE

  2. 2. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    University dissertation from Wallenberg Neuroscience Center, BMC, Lund University

    Author : Oskar Hansson; Lunds universitet.; Lund University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; basal ganglia; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. READ MORE

  3. 3. Effects of immunosuppressive drugs on human adipose tissue metabolism

    University dissertation from Wallenberg Neuroscience Center, BMC, Lund University

    Author : Maria J Pereira; Göteborgs universitet.; Gothenburg University.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Abstract : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. READ MORE