Search for dissertations about: "carbonic anhydrase II"

Showing result 1 - 5 of 26 swedish dissertations containing the words carbonic anhydrase II.

  2. 1. The Interaction Between the Chaperonin GroEL and Human Carbonic Anhydrase II : Protein Folding and Stability Studies

    Author : Malin Persson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbonic anhydrase; protein folding; protein stability; chaperone; GroEL; folding mechanism; site-directed spinlabeling; electron paramagnetic resonance EPR ;

    Abstract : The presence of GroEL/ES during the refolding of human carbonic anhydrase II was found to increase the yield of active enzyme from approx. 70 to approx. 100%. This chaperone action on the enzyme could be obtained by adding GroEL alone, and the time course in that case was only moderately slower than the spontaneous process. READ MORE

  4. 2. Studies of native and Cd(II)-substituted carbonic anhydrases with special reference to their interaction with inhibitors

    Author : Lena Tibell; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbonic anhydrase; Cd II ; 113-Cd II -NMR; inhibition; catalytic mechanism;

    Abstract : The major aim of this work has been to gain further insights into the catalytic mechanism of carbonic anhydrase (carbonate hydro-lyase, EC 4.2.1.1). READ MORE

  5. 3. Engineering carbonic anhydrase for highly selective ester hydrolysis

    Author : Gunnar Höst; Bengt-Harald Jonsson; Lars-Göran Mårtensson; Per Berglund; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbonic anhydrase; specificity; hydrolysis; rational design; protein engineering; plasmodium falciparum; Bioengineering; Bioteknik;

    Abstract : I denna avhandling presenteras arbete utfört med enzymet humant karboanhydras II (HCAII). Enzymer är en typ av proteiner som accelererar (katalyserar) kemiska reaktioner, vilket är nödvändigt för allt levande. Den naturliga funktionen för HCAII är att katalysera omvandlingen av gasen koldioxid till vätekarbonat, som är löslig i vätska. READ MORE

  6. 4. Pharmacological therapy in obstructive sleep apnea - Methodology and interventional aspects of carbonic anhydrase modulation

    Author : Erik Hoff; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; obstructive sleep apnea; carbonic anhydrase; endotype; drug therapy; hypoxia; hypoxia-inducible factor 1α; placebo;

    Abstract : BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent disease with potential severe short- and long-term consequences such as daytime sleepiness and cardiovascular disease. Recurrent total or partial collapse of the upper airway during sleep leads to sleep fragmentation and intermittent hypoxia/hypercapnia. READ MORE

  7. 5. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

    Author : Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
    Keywords : Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

    Abstract : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. READ MORE