Search for dissertations about: "cathepsin L"
Showing result 1 - 5 of 24 swedish dissertations containing the words cathepsin L.
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1. Identification of abnormally expressed genes in skeletal muscle contributing to insulin resistance and type 2 diabetes
Abstract : The metabolic defects of insulin resistance and type 2 diabetes can result from changes in gene expression and protein functions due to genetic and environmental influences. The aim of this study was to identify abnormally expressed genes associated with insulin resistance or type 2 diabetes, and further to test whether possible defects are inherited or acquired. READ MORE
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2. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice
Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE
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3. Cathepsin D released from lysosomes mediates apoptosis
Abstract : Last year (2002), the Nobel Prize in Physiology or Medicine was awarded to three scientists who have conducted pioneer research on programmed cell death. In the human body, more than a thousand billion cells are created every day, and an equal number die, thus programmed cell death, or apoptosis, is an important mechanism for maintaining tissue homeostasis and protecting against disease. READ MORE
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4. Prion processing and propagation in neuronal and dendritic cell culture models
Abstract : Prion diseases are rare neurodegenerative diseases, associated with a conversion of a normal cellular protein, PrPC, into its misfolded and partial protease resistant isoform, PrPSc. These diseases affect both animals and humans and are unique since they can not only be genetic and sporadic, but also transmissible. READ MORE
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5. Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases
Abstract : Osteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. READ MORE