Search for dissertations about: "cefuroxime"

Showing result 1 - 5 of 14 swedish dissertations containing the word cefuroxime.

2. 1. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime

   Author : Anders Viberg; Marie Sandström; Otto Cars; Mats Karlsson; Hartmut Derendorf; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cefuroxime; pharmacokinetics; pharmacodynamics; dosing individualisation; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

   Abstract : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. READ MORE

4. 2. Serum Amyloid A Protein (SAA) in Healthy and Infected Individuals

   Author : Anders Lannergård; Göran Friman; Anders Larsson; Uwe Ewald; Jonas Hedlund; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; acute phase proteins; adult; Administration Oral; aminoglycosides; amyloidosis; antibiotics; bacterial infections; body temperature; C-reactive protein; cefuroxime; cystitis; cytokines; elderly; infant; interleukin-6; newborn; pyelonephritis; serum amyloid A protein; virus diseases; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

   Abstract : Serum amyloid A protein (SAA) is an acute phase protein that has recently gained increasing interest as a potential marker for disease and treatment monitoring. We investigated SAA and CRP levels in (a) patients with various common infectious diseases (n=98), (b) patients with pyelonephritis (n=37) versus patients with cystitis (n=32), (c) healthy individuals of varying ages (n=231), (d) very immature newborn infants with or without nosocomial infections (NIs) (n=72) and (e) patients with bacterial infections treated with cefuroxime (n=81). READ MORE

5. 3. Pharmacometrics to characterize innate immune response and antibacterial treatments

   Author : Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. READ MORE

6. 4. Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors

   Author : Gisela Wejde; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Posterior capsule opacification; postoperative endophthalmitis; cataract surgery; capsulorhexis; intraocular lens; acrylic hydrophobic IOL; HSM PMMA IOL; silicone IOL; round edge; sharp edge; prophylaxis; cefuroxime;

   Abstract : Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule opacification (PCO) and the rare but serious complication postoperative endophthalmitis (POE). READ MORE

7. 5. Antibiotic resistance in Gram-negative bacilli : with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae

   Author : Owe Källman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Objectives: The objectives of this thesis were to study mechanisms conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum beta-lactamase) producing isolates of Escherichia coli and Klebsiella pneumoniae, as well as the presence of co-resistance to other antibiotics in the K. pneumoniae isolates. READ MORE